Subcutaneous
metastasis from
colorectal cancer is an unusual presentation. Most perineal subcutaneous
metastases are found in extensive involvements of multiorgan
metastases or local
recurrences of
rectal cancer. Subcutaneous
metastasis from
colon cancer is considered as a distant
metastasis with poor
prognosis. We
report an unusual case of solitary subcutaneous
metastasis beneath the
perineum without solid organ involvement after a curative anterior resection for
sigmoid colon cancer. The
patient underwent a perineal resection, and
chemotherapy with the FOLFOX (
fluorouracil,
leucovorin, and
oxaliplatin) regimen was instituted. Eight months later, multiple
lung metastases were found, and
chemotherapy was restarted with the FOLFIRI (
fluorouracil,
leucovorin, and
irinotecan) regimen. However,
lung metastases progressed, and new
metastases appeared at the
adrenal glands, the
kidneys and the
cerebellum. The
patient died 30 months after the
diagnosis of perineal subcutaneous
metastasis. He lived relatively long in comparison with
patients in previous
reports.