Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice / 대한배뇨장애요실금학회지
Seheon JUNG; Sun-Ouck KIM; Kyung-Aa CHO; Seung-Hee SONG; Teak-Won KANG; Kwangsung PARK; Dongdeuk KWON.
International Neurourology Journal
; : 34-38, 2015.
Artículo
en Inglés
| WPRIM | ID: wpr-145430
PURPOSE:
It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identify their relation in the urothelium of the urinary bladder.METHODS:
The cellular localization and expressions of aquaporin 1 and caveolin 1, in the wild type and caveolin 1 knockout mice urinary bladder, were examined by Western blot and immunofluorescence techniques.RESULTS:
Aquaporin 1 and caveolin 1 were coexpressed in the arterioles, venules, and capillaries of the suburothelial layer in the wild type controls. Aquaporin 1 protein expression was significantly higher in the caveolin 1 knockout mice than in the wild type controls (P <0.05).CONCLUSIONS:
The results imply that aquaporin 1 and caveolin 1 may share a distinct relation with the bladder signal activity. This might play a specific role in bladder dysfunction.
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WPRO
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