A Case of Ectopic Adrenocorticotropic Hormone Syndrome in Small Cell Lung Cancer / 결핵및호흡기질환
Chaiho JEONG; Jinhee LEE; Seongyul RYU; Hwa-Young LEE; Ah-Young SHIN; Ju-Sang KIM; Joong-Hyun AHN; Hye-Seon KANG.
Tuberculosis and Respiratory Diseases
; : 436-439, 2015.
Artículo
en Inglés
| WPRIM | ID: wpr-149065
Small cell lung cancer (SCLC), which originated from neuroendocrine tissue, can develop into paraneoplastic endocrine syndromes, such as Cushing syndrome, because of an inappropriate secretion of ectopic adrenocorticotropic hormone (ACTH). This paraneoplastic syndrome is known to be a poor prognostic factor in SCLC. The reason for poor survival may be because of a higher risk of infection associated with hypercortisolemia. Therefore, early detection and appropriate treatment for this syndrome is necessary. But the diagnosis is challenging and the source of ACTH production can be difficult to identify. We report a 69-year-old male patient who had severe hypokalemia, metabolic alkalosis, and hypertension as manifestations of an ACTH-secreting small cell carcinoma of the lung. He was treated with ketoconazole and spironolactone to control the ACTH dependent Cushing syndrome. He survived for 15 months after chemotherapy, which is unusual considering the poor outcome of the ectopic ATH syndrome associated with SCLC.
Biblioteca responsable:
WPRO
Texto completo
Documentos relacionados