Inflammation is closely related to the progression of
cancer as well as
tumorigenesis. Here, we investigated the effect of
prostaglandin E2 (
PGE2) and
interleukin-1beta (IL-1beta) on
E-cadherin expression in SNU719
gastric cancer cells.
E-cadherin expression decreased as the
dose or
exposure time of
PGE2 and IL-1beta increased, whereas
Snail expression increased with
dose or
time of
PGE2 and IL-1beta.
E-cadherin expression reduced by
PGE2 treatment increased after the
transfection of
Snail siRNA. Neutralization of IL-1beta using anti-IL-1beta antibody blocked the expression pattern of
E-cadherin and
Snail occurred by IL-1beta
treatment. However, there was no synergic effect of IL-1beta and
PGE2 on the expression pattern of
E-cadherin and
Snail. In conclusion, inflammatory mediators reduced
E-cadherin expression by enhancing
Snail expression in
gastric cancer cells.
Inflammation-induced transcriptional
regulation of
E-cadherin in
gastric cancer has implications for targeted
chemoprevention and
therapy.