Hemolytic uremic syndrome (HUS) is a rare disorder characterized by the triad of
microangiopathic hemolytic anemia,
thrombocytopenia, and
acute renal failure. HUS arises from a wide spectrum of conditions, and chemotherapeutic agents have been reported to be associated with HUS, including
Mitomycin,
Cisplatin,
Bleomycin, and
Gemcitabine. A 76-year-old man treated with
Gemcitabine due to
non-small cell lung cancer developed clinical and
laboratory findings compatible with HUS.
Gemcitabine was ceased and
hemodialysis and
plasma exchange were utilized and he recovered. A high level of suspicion for HUS is necessary when
cancer patients are treated with
Gemcitabine, and prompt recognition and
treatment are also essential.