Primary duodenal
adenocarcinoma is a rare
malignant neoplasm accounting for 0.3% of all
gastrointestinal tract carcinomas. We herein present one case of duodenal
adenocarcinoma after duodenal
neuroendocrine carcinoma. Poorly differentiated duodenal
neuroendocrine carcinoma with
liver metastasis (TxNxM1) was confirmed, and eight cycles of palliative
chemotherapy (
5-fluorouracil/
etoposide/
cisplatin) were administered. The
patient was then in a clinically complete response status. About 1 year later, newly developed
adenocarcinoma was detected at the same site. It was completely surgically resected, and the
patient was cured.