The effects of
sevoflurane and subsequent
administration of
diltiazem on intrapulmonary shunt and
oxygenation were studied in
pentobarbital anesthetized
dogs. After
inhalation of 1MAC of
sevoflurane and subsequent
intravenous administration of clinical
dose of
diltiazem (loading
dose 0.2 mg/kg,
maintenance dose 0.01 mg/kg/min), there were no changes in
cardiac output, arterial
oxygen tension, mixed venous
oxygen tension,
oxygen transport,
oxygen consumption, intrapul-monary shunt ratio,
pulmonary vascular resistance, alveolar-arterial
oxygen difference. After
intravenous administration of
diltiazem with bolus (0.4 mg/kg) and
maintenance dose (0.02 mg/ kg/min),
pulmonary vascular resistance was significantly decreased (p<0.05) but the other
parameters indicating pulmonaruy
hemodynamics and
oxygenation were unchanged. These results suggest that concomittent use of the two classes of
drugs is not induce significant changes in pulmonary
hemodynamic and
oxygenation, and can be used safely in
patient with normal cardiopulmonary function when clinical concentration of both were used.