The
combination chemotherapy of
irinotecan with
5-fluorouracil and
leucovorin (FOLFIRI regimen) was recently proven to be beneficial in
patients with advanced
colorectal cancer. Pulmonary
toxicity is very rare in
adverse effects of
irinotecan. No case of
organizing pneumonia (also known as
bronchiolitis obliterans organizing pneumonia) associated with FOLFIRI
chemotherapy has been reported. We experienced a case of a 62-year-old man
who presented persistent dry
cough and progressive
dyspnea after receiving
chemotherapy with FOLFIRI regimen. After surgical
lung biopsy, the
patient was diagnosed with FOLFIRI
chemotherapy-induced
organizing pneumonia which was successfully treated with
steroid therapy.