It has been reported that microalbuminuria is associated with increased cardiovascular mortality in both diabetic and non-diabetic subjects. This study was initiated to see whether microalbuminuria is associated with cardiovascular risk factor in Korean non-diabetic subjects.
METHODS:
We examined various correlates of microalbuminuria in 221 non-diabetic subjects aged 50-59 years who visited health promotion center of Asan medical center.
RESULTS:
1) Microalbuminuria was detected in 7%(15/211) of Korean non-diabetic subjects. 2) The subjects with microalbuminuria had higher BMI(25.0 vs. 23.8kg/m2), higher systolic and diastolic blood pressure(143/87 vs, 124/95mmHg), higher serumcholesterol(220 vs. 201mg/dL), higher triglyceride(151 vs. 99mg/dL), higher fastinginsulin levels(9.8 vs. 6.1 microU/ml) than the subjects with normoalbuminuria. 3) Multiple logistic regressionanalysis revealed that microalbuminuria was independently related to age, blood pressure, and fastingseruminsulin levels.
CONCLUSION:
We found that significant proportion of Korean non-diabetic subjects had microalbuminuria. Microalbuminuria was associated with various cardiovascular risk factors including higher fastingseruminsulin level. These findings suggest that microalbuminuria may form part of the insulin resistancesyndrome, so called 'Syndrome X'.