Molecular Neuroimaging in Posttraumatic Stress Disorder
Jooyeon-Jamie IM; Eun NAMGUNG; Yejee CHOI; Jung-Yoon KIM; Sandy-Jeong RHIE; Sujung YOON.
Experimental Neurobiology
; : 277-295, 2016.
Artículo
en Inglés
| WPRIM | ID: wpr-172191
Over the past decade, an increasing number of neuroimaging studies have provided insight into the neurobiological mechanisms of posttraumatic stress disorder (PSTD). In particular, molecular neuroimaging techniques have been employed in examining metabolic and neurochemical processes in PTSD. This article reviews molecular neuroimaging studies in PTSD and focuses on findings using three imaging modalities including positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance spectroscopy (MRS). Although there were some inconsistences in the findings, patients with PTSD showed altered cerebral metabolism and perfusion, receptor bindings, and metabolite profiles in the limbic regions, medial prefrontal cortex, and temporal cortex. Studies that have investigated brain correlates of treatment response are also reviewed. Lastly, the limitations of the molecular neuroimaging studies and potential future research directions are discussed.
Biblioteca responsable:
WPRO
Texto completo
Documentos relacionados