PURPOSE:
Continuous renal replacement therapy (CRRT) has been used widely for treating
critically ill patients with
acute renal failure (ARF). We performed this study to identify predictors of
mortality in
critically ill ARF
patients treated with CRRT.
METHODS:
We analyzed the data of 128
patients who were treated with
continuous veno-venous hemofiltration (CVVH) or
continuous veno-venous hemodiafiltration (
CVVHDF) from May, 2002 to March, 2008. We compared the clinical data of
survivors with non-
survivors.
RESULTS:
On univariate analyses of
prognostic factors of
patients treated with
CVVHDF,
APACHE II scores (p=0.004),
prothrombin time (
INR) (p=0.033) and the number of inotropics used (p=0.005) were significantly lower in
survivors than those of non-
survivors. MAP (p=0.027), diastolic BP (p=0.015) and
fibrinogen level (p=0.007) were significantly higher in
survivors than those of non-
survivors.
Multivariate analysis revealed that
APACHE II scores and
fibrinogen level were the independent factors for the prediction of
mortality. And on univariate analyses of
prognostic factors of
patients treated with CVVH,
APACHE II scores (p=0.002) and the number of inotropics used (p=0.006) were significantly lower in
survivors than in non-
survivors. MAP (p=0.03), systolic BP (p=0.02) and diastolic BP (p=0.03) were significantly higher in
survivors than in non-
survivors.
Multivariate analysis also revealed that
APACHE II scores was the only independent factor for the prediction of
mortality.
CONCLUSION:
This study showed that the independent
prognostic factor for
mortality in ARF
patients treated with CRRT was the
APACHE II score.