Matrix metalloproteinase-8 and substance P levels in root canal exudates of nonvital teeth / 대한치과보존학회지
Su-Jung SHIN; Woocheol LEE; Jae-Il LEE; Seung-Ho BAEK; Kee-Yeon KUM; Won-Jun SHON; Kwang-Shik BAE.
Journal of Korean Academy of Conservative Dentistry
; : 196-202, 2011.
Artículo
en Ko
| WPRIM | ID: wpr-19516
OBJECTIVES:
The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in root canal exudates during root canal treatment (RCT) of nonvital, painful teeth. MATERIALS ANDMETHODS:
Patients scheduled for nonsurgical RCT were prospectively selected; the study was performed after obtaining informed consent from the patients and was approved by the Institutional Review Board for Clinical Research of Gangnam Severance Hospital, Yonsei University (3-2008-0118). Canal exudates samples were collected using sterilized paper points from teeth scheduled for RCT across three different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis (p < 0.05).RESULTS:
MMP-8 and SP levels in GCF were decreased during RCT (p < 0.0001), and they showed a weak positive correlation to each other (p < 0.05). Patients'subjective pain levels and the response from percussion test were significantly related to SP level.CONCLUSIONS:
This study demonstrated that periradicular inflammation endodontic origin can elevate SP and MMP-8 levels in root canal exudates. Interestingly, SP level of canal exudates showed a possibility of being used as an indicator of pain due to periapical pathosis.
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WPRO
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