Validation of the Oxford Classification of IgA Nephropathy: A Single-Center Study in Korean Adults
Hoyoung LEE; Sul-Hee YI; Mi-Seon SEO; Jin-Nam HYUN; Jin-Seok JEON; Hyunjin NOH; Dong-Cheol HAN; Seung-Duk HWANG; So-Young JIN; Soon-Hyo KWON.
The Korean Journal of Internal Medicine
; : 293-300, 2012.
Artículo
en Inglés
| WPRIM | ID: wpr-195164
BACKGROUND/
AIMS:
The recently published Oxford classification of IgA nephropathy (IgAN) proposed a split system for histological grading, based on prognostic pathological features. This new classification system must be validated in a variety of cohorts. We investigated whether these pathological features were applicable to an adult Korean population.METHODS:
In total, 69 adult Korean patients with IgAN were analyzed using the Oxford classification system at Soonchunhyang University Hospital, Seoul, Korea. All cases were categorized according to Lee's classification. Renal biopsies from all patients were scored by a pathologist who was blinded to the clinical data for pathological variables. Inclusion criteria were age greater than 18 years and at least 36 months of follow-up. We excluded cases with secondary IgAN, diabetic nephropathy combined other glomerulopathies, less than 36 months of follow-up, and those that progressed rapidly.RESULTS:
The median age of the patients was 34 years (range, 27 to 45). Mean arterial blood pressure was 97 +/- 10 mmHg at the time of biopsy. The median follow-up period was 85 months (range, 60 to 114). Kaplan-Meier analysis showed significant prognostic predictions for M, E, and T lesions. A Cox proportional hazard regression analysis also revealed prognostic predictions for E and T lesions.CONCLUSIONS:
Using the Oxford classification in IgAN, E, and T lesions predicted renal outcome in Korean adults after taking clinical variables into account.Asunto(s)
Adulto Femenino Humanos Masculino Persona de Mediana Edad Pueblo Asiatico Biopsia Distribución de Chi-Cuadrado Progresión de la Enfermedad Aceites de Pescado/uso terapéutico Glomerulonefritis por IGA/clasificación Hospitales Universitarios Inmunosupresores/uso terapéutico Estimación de Kaplan-Meier Riñón/patología Análisis Multivariante Valor Predictivo de las Pruebas Pronóstico Modelos de Riesgos Proporcionales Reproducibilidad de los Resultados República de Corea/epidemiología Estudios Retrospectivos Índice de Severidad de la Enfermedad Factores de Tiempo
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