Neurogenesis can be induced by pathological conditions such as
cerebral ischemia. However the molecular mechanisms or modulating
reagents of the reactive
neurogenesis after the
cerebral ischemia are poorly characterized.
Retinoic acid (RA) has been shown to increase
neurogenesis by enhancing the proliferation and neuronal differentiation of
forebrain neuroblasts. Here, we examined whether RA can modulate the reactive
neurogenesis after the
cerebral ischemia. In contrast to our
expectation, RA
treatment decreased the reactive
neurogenesis in
subventricular zone (SVZ), subgranular zone (SGZ) and penumbral region. Furthermore, RA
treatment also decreased the
angiogenesis and
gliosis in penumbral region.