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Genome-wide Association Study Identified TIMP2 Genetic Variant with Susceptibility to Osteoarthritis

Bhumsuk KEAM; Joo-Yeon HWANG; Min-Jin GO; Jee-Yeon HEO; Mi-Sun PARK; Ji-Young LEE; Nam-Hee KIM; Miey PARK; Ji-Hee OH; Dong-Hyun KIM; Jin-Young JEONG; Jong-Young LEE; Bok-Ghee HAN; Juyoung LEE.
Genomics & Informatics ; : 121-126, 2011.
Artículo en Inglés | WPRIM | ID: wpr-205647
Osteoarthritis (OA) is the most common degenerative joint disorder in the elderly population. To identify OA-associated genetic variants and candidate genes, we conducted a genome-wide association study (GWAS). A total 3,793 samples (476 cases wrist + knee and 3317 controls) from a community-based epidemiological study were genotyped using the Affymetrix SNP 5.0. An intronic SNP (rs4789934) in the TIMP2 (tissue inhibitor of metalloproteinase-2) showed the most significance with OA (odd ratio [OR] = 2.06, 95% confidence interval [CI] = 1.52-2.81, p = 4.01 x 10(-6)). Furthermore, a polymorphism (rs1352677) in the NKAIN2 (Na+/K+ transporting ATPase interacting 2) was suggestively associated with OA (OR = 1.43, CI = 1.22-1.66, p = 7.01 x 10(-6)). The present study provides new insights into the identification of genetic predisposing factors for OA.
Biblioteca responsable: WPRO