Metabolic Complications among Korean Patients with HIV Infection: The Korea HIV/AIDS Cohort Study
Dong-Hyun OH; Jin-Young AHN; Sang-Il KIM; Min-Ja KIM; Jun-Hee WOO; Woo-Joo KIM; Ji-Hyeon BAEK; Shin-Woo KIM; Bo-Youl CHOI; Mi-Hwa LEE; Ju-Yeon CHOI; Myung-Guk HAN; Chun KANG; June-Myung KIM; Jun-Yong CHOI.
Journal of Korean Medical Science
; : 1268-1274, 2017.
Artículo
en Inglés
| WPRIM | ID: wpr-210876
Currently, metabolic complications are the most common problem among human immunodeficiency virus (HIV)-infected patients, with a high incidence. However, there have been very few studies regarding metabolic abnormalities published in Asia, especially in Korea. This cross-sectional study was performed to investigate the prevalence of and risk factors for metabolic abnormalities in 1,096 HIV-infected patients of the Korea HIV/AIDS cohort study enrolled from 19 hospitals between 2006 and 2013. Data at entry to cohort were analyzed. As a result, the median age of the 1,096 enrolled subjects was 46 years, and most patients were men (92.8%). The metabolic profiles of the patients were as follows median weight was 63.8 kg, median body mass index (BMI) was 22.2 kg/m², and 16.4% of the patients had a BMI over 25 kg/m². A total of 5.5% of the patients had abdominal obesity (waist/hip ratio ≥ 1 in men, ≥ 0.85 in women). Increased levels of fasting glucose, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were present in 10.4%, 6.0%, 5.5%, and 32.1% of the patients. Decreased high-density lipoprotein (HDL) cholesterol levels were observed in 44.2% of the patients. High systolic blood pressure was present in 14.3% of the patients. In multivariate analysis, high BMI and the use of protease inhibitors (PIs) were risk factors for dyslipidemia in HIV-infected patients. In conclusion, proper diagnosis and management should be offered for the prevalent metabolic complications of Korean HIV-infected patients. Further studies on risk factors for metabolic complications are needed.
Asunto(s)
Humanos Masculino Asia Presión Sanguínea Índice de Masa Corporal Colesterol Estudios de Cohortes Estudios Transversales Diagnóstico Dislipidemias Ayuno Glucosa Infecciones por VIH VIH Incidencia Corea (Geográfico) Lipoproteínas Metaboloma Análisis Multivariante Obesidad Abdominal Prevalencia Inhibidores de Proteasas Factores de Riesgo Triglicéridos
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