Early monitoring for detection of antituberculous drug-induced hepatotoxicity
Chang-Min LEE; Sang-Soo LEE; Jeong-Mi LEE; Hyun-Chin CHO; Wan-Soo KIM; Hong-Jun KIM; Chang-Yoon HA; Hyun-Jin KIM; Tae-Hyo KIM; Woon-Tae JUNG; Ok-Jae LEE.
The Korean Journal of Internal Medicine
; : 65-72, 2016.
Artículo
en Inglés
| WPRIM | ID: wpr-220501
BACKGROUND/
AIMS:
We investigated the time of onset of antituberculous drug-induced hepatotoxicity (ADIH) and related characteristics.METHODS:
Adult patients (n = 1,031) treated with first-line antituberculous drugs between February 2009 and January 2013 were enrolled.RESULTS:
Of the 1,031 patients, 108 patients (10.5%) developed ADIH a mean of 39.6 +/- 43.7 days after treatment initiation. Twenty-eight patients (25.9%) developed ADIH within 7 days, 73 (67.6%) within 30 days, and the rest after 30 days. The 30-day group. In subgroup analysis, the 40 IU/L (odds ratio [OR], 2.995; 95% confidence interval [CI], 1.580 to 5.680; p = 0.001) and presence of anti-hepatitis C virus (OR, 4.204; 95% CI, 1.822 to 9.700, p = 0.001) were independent risk factors for development of ADIH.CONCLUSIONS:
Approximately 70% of the cases of ADIH occurred in the first month of antituberculous treatment, and were associated with continuation of the first-line drug regimen.
Biblioteca responsable:
WPRO
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