Alteration of Ventricular Repolarization by Intracoronary Infusion of Normal Saline in Patients With Variant Angina
Jae-Kwon KIM; Nam-Ho KIM; Ik-Sang SHIN; Dong-Hyo NOH; Yong-Cheol KIM; Seung-Hwan KIM; Jun-Ho CHOI; Eun-Mi PARK; Sang-Jae LEE; Kyeong-Ho YUN; Nam-Jin YOO; Eun-Mi LEE; Seok-Kyu OH; Jin-Won JEONG.
Korean Circulation Journal
; : 223-227, 2009.
Artículo
en Inglés
| WPRIM | ID: wpr-221156
BACKGROUND AND
OBJECTIVES:
During coronary angiography and interventional procedures, catheters that are engaged in a coronary ostium are routinely flushed, typically with normal saline, to expel blood from the catheter or to inject a pharmacologic agent. Saline contains sodium and chloride ions. Such injections may affect the electrophysiologic properties of the myocardium; however, the effect of normal saline on ventricular repolarization has not been established in patients with variant angina. SUBJECTS ANDMETHODS:
We studied 51 consecutive patients with variant angina. Five mL of normal saline (NS) or 5% dextrose solution (DW) were infused into the left coronary artery in random order. We measured the heart rate, QT interval, and T-wave amplitude using Mac-Lac 5.2.RESULTS:
The baseline clinical characteristics were not different between the NS {n=30 (14 males); mean age, 56+/-10 years} and the 5% DW groups {n=21 (7 males); mean age, 59+/-10 years}. The changes in the mean corrected QT (QTc) interval were significantly increased at the time of infusion of NS compared to 5% DW (45.1+/-30.3 vs. 20.9+/-23.3 ms, p=0.004). There was a T-wave amplitude change >0.2 mV in at least one-lead in 27 patients (90.0%) during NS infusion compared to 7 patients (33.3%) during 5% DW infusions (p=0.001). No significant changes in heart rate and blood pressure were noted during of the infusions.CONCLUSION:
NS was associated with prolongation of ventricular repolarization in patients with variant angina.
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