<p><b>OBJECTIVE</b>To investigate the
association of the 4G/5G polymorphism located in the
promoter region of
plasminogen activator inhibitor-1(
PAI-1)
gene with
prognosis of
coronary artery disease (CAD) in
Chinese Hans.</p><p><b>
METHODS</b>One hundred and fifty five
patients with CAD and 190 unrelated healthy control individuals were included in the study. The 4G/5G polymorphism was detected by
polymerase chain reaction-
restriction fragment length polymorphism (
PCR-
RFLP)
analysis. A follow-up
survey of major adverse cardiovascular event (
MACE) and
analysis of the relationship between the severity of
coronary vessels and
PAI-1 gene polymorphism were carried out.</p><p><b>RESULTS</b>(1) The frequency of 4G/4G
genotype of
PAI-1 gene was higher in CAD
patients than in controls (58/155, 37.42% vs 52/190, 27.37%, P< 0.01). (2) The frequency of 4G/4G
genotype of
PAI-1 in
patients with
MACE was higher than that in
patients without
MACE (40/81, 49.38% vs 18/74, 23.42%; P< 0.01). (3) The frequency of 4G/4G
genotype in
patients with multivessel
disease was higher than that in
patients with single-vessel
disease (30/47, 44.77% vs 9/37, 24.32%; P< 0.05).</p><p><b>CONCLUSION</b>The 4G/5G polymorphism located in the
promoter region of
PAI-1 gene was associated with
prognosis of CAD
patients, and may be regarded as a
biomarker of the severity of the involved vessels.</p>