Association between A1168C polymorphism in PAX4 gene and type 1 diabetes in Han Chinese / 中国医学科学院学报
Yun ZHANG; Xin-hua XIAO; Heng WANG; Tong WANG; Qi SUN; Guo-hua YANG; Yong FU; Tao YUAN; Qian ZHANG; Qiu-ying LIU.
Acta Academiae Medicinae Sinicae
; (6): 370-373, 2007.
Artículo
en Zh
| WPRIM | ID: wpr-229972
<p><b>OBJECTIVE</b>To explore whether A1168C polymorphisms in paired box gene 4 (PAX4) are associated with type 1 diabetes mellitus (T1DM) in Chinese Han population.</p><p><b>METHODS</b>Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype A1168C polymorphisms in PAX4 gene. Totally 109 patients with T1DM and 251 control subjects were recruited. The frequency distributions of genotypes between two groups were analyzed by SPSS software.</p><p><b>RESULTS</b>The genotype distributions were in Hardy-Weinberg equilibrium both among T1DM cases and control subjects. No difference was observed in the genotype frequencies and allele frequencies between T1DM cases and control subjects (P > 0.05), nor was any disease association detected when patients were stratified according to age at diagnosis or sex (P > 0.05).</p><p><b>CONCLUSION</b>The A1168C single nucleotide polymorphism in PAX4 gene may not play an essential role in genetic T1DM susceptibility in Chinese Han population.</p>
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