Design, synthesis and Na+/H+ exchanger isoform-1 inhibitory activity of feruloylagmatine analogues / 药学学报
Jia-Ming LI; Yong HE; Peng ZHOU; Yun-Gen XU; Jia-Zhi PENG; Ri-Zheng SHENG.
Acta Pharmaceutica Sinica
; (12): 936-941, 2011.
Artículo
en Zh
| WPRIM | ID: wpr-233073
In order to search for novel inhibitors of Na+/H+ exchanger isoform-1 (NHE-1), nine feruloylagmatine analogues were designed and synthesized from ferulic acid and agmatine. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR and mass spectra, among which compounds 5f-5i were novel compounds. The results of preliminary pharmacological test showed that some of the compounds possessed strong NHE-1 inhibitory activity, among which compounds 5a, 5b and 6c were more potent than cariporide in NHE-1 inhibition.
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