Study on the genotyping and microevolution of Yersinia pestis in the Qinghai-Tibet Plateau / 中华流行病学杂志
Min LI; Er-hei DAI; Rui-xia DAI; Dong-sheng ZHOU; Xiao-yan YANG; Bai-zhong CUI; Li-xia JIN; Hai-hong ZHAO; Cun-xiang LI; Mei-ying QI; Dun-zhu Ci REN; Xiang DAI; Yong-jiao TANG; Rui-fu YANG.
Chinese Journal of Epidemiology
; (12): 412-415, 2006.
Artículo
en Zh
| WPRIM | ID: wpr-233936
<p><b>OBJECTIVE</b>To study the distribution of genomovars and microevolution of Yersinia pestis in the Qinghai-Tibet Plateau.</p><p><b>METHODS</b>Primer pairs targeting the twenty-two different regions(DFRs) were designed for detecting the presence or deletion of each DFR in 297 strains isolated from the Qinghai-Tibet Plateau.</p><p><b>RESULTS</b>9 genomovars, i. e. Genomovar 1, 5, 6, 7, 8, 10, 11, new type and Ype-ancestor were identified in the Marmota himalayana plague focus of the Qinghai-Tibet Plateau. Among these genomovars, genomovar 5,8 and 10 were dominant types. The total rate of the three genomovars was 80.6% (204/253) and the genomovars in different regions were different. All of 44 strains of Y. pestis in the Microtus fuscus plague focus of the Qinghai-Tibet Plateau belonged to genomovar 14.</p><p><b>CONCLUSION</b>The distribution of genomovars of Y. pestis in the Qinghai-Tibet plateau had remarkable characteristics geographically. Based on the distribution of genomovars of Y. pestis, the routes of transmission and microevolution of Y. pestis were proposed.</p>
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