This study was aimed to evaluate the relationship between the changes of
plasma intermedin (IMD) and atrial
fibrosis in hypertensive
patients with
atrial fibrillation. During the period from 2010 to 2011, appropriate 150 subjects of
out-patients (
female 50%,
male 50%) were selected in West
China Hospital, Sichuan
University, and were divided into three groups the
hypertension-only group, the
hypertension combined with
paroxysmal atrial fibrillation group and the
hypertension combined with
persistent atrial fibrillation group. Firstly, we collected the
Physical examination results and medical
history records of the
patients. We then performed ultrasound cardiogram and
blood biochemical tests on the
patients. We also detected the
plasma IMD and
transforming growth factor β1 (TGF-β1) using
ELISA. The results showed that compared with the hypertensive group, the
plasma level of IMD, TGF-β1 and
left atrium director (LAD) in the hypertensive combined with
atrial fibrillation group were higher significantly. Compared with the paroxymal
atrial fibrillation group, the levels of IMD, TGF-β1 and LAD were higher significantly in
persistent atrial fibrillation group.
Analysis of correlation and partial correlation showed that IMD was positively correlated with TGF-p1 (r=0.51, P<0. 001), IMD was positively correlated with LAD(r=0.59, P< 0.001), and TGF-β1 was positively correlated with LAD (r = 0.57, P < 0.001). The results suggest that IMD might suppress the pathophysiological process of
atrial fibrillation.