Salicylic acid derivatives as simplified and novel GK small molecule activators / 药学学报
Lian-Chao HUO; Yu-Liang ZHANG; Lei LEI; Shuai-Nan LIU; Zhu-Fang SHEN; Yu-Ling WANG; Hong-Rui SONG; Zhi-Qiang FENG.
Acta Pharmaceutica Sinica
; (12): 514-520, 2013.
Artículo
en Zh
| WPRIM | ID: wpr-235635
Glucokinase (GK) is a new target for the treatment of type II diabetes mellitus (T2DM). In order to find a structure-simplified small molecule GK activator, 19 salicylic acid derivatives were designed and synthesized based on new lead compound (1). Experimental results showed that the potency of compound 8h is superior to control RO-28-0450 in GK activation.
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