Knee pain is rarely an initial symptom of
colon cancer, because most
bone metastases develop in the late stage of
cancer. Therefore,
patients with
colorectal cancer usually present with gastrointestinal symptoms. Recently, we experienced a 46-year-old
female with
rectal cancer that presented as
knee pain due to tibial
metastasis without other organ
metastasis. She was evaluated for
knee pain and diagnosed with a
rectal cancer after
biopsies of the tibial and rectal masses. We
report the first such case in
Korea with a
review of the
literature.