Analysis of rational clinical uses of traditional Chinese medicine injections and factors influencing adverse drug reactions / 中国中药杂志
Shi-Guang SUN; Zi-Feng LI; Yan-Ming XIE; Jian LIU; Yan LU; Yi-Fei SONG; Ying-Hua HAN; Li-Da LIU; Ting-Ting PENG.
China Journal of Chinese Materia Medica
; (24): 2969-2973, 2013.
Artículo
en Zh
| WPRIM | ID: wpr-238573
<p><b>OBJECTIVE</b>To rationalize the clinical use and safety are some of the key issues in the surveillance of traditional Chinese medicine injections (TCMIs).</p><p><b>METHOD</b>In this 2011 study, 240 medical records of patients who had been discharged following treatment with TCMIs between 1 and 12 month previously were randomly selected from hospital records. Consistency between clinical use and the description of TCMIs was evaluated. Research on drug use and adverse drug reactions/events using logistic regression analysis was carried out.</p><p><b>RESULT</b>There was poor consistency between clinical use and best practice advised in manuals on TCMIs. Over-dosage and overly concentrated administration of TCMIs occurred, with the outcome of modifying properties of the blood. Logistic regression analysis showed that, drug concentration was a valid predictor for both adverse drug reactions/events and benefits associated with TCMIs.</p><p><b>CONCLUSION</b>Surveillance of rational clinical use and safety of TCMIs finds that clinical use should be consistent with technical drug manual specifications, and drug use should draw on multi-layered logistic regression analysis research to help avoid adverse drug reactions/events.</p>
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