Expert consensus on population pharmacokinetics of Chinese medicine ( draft version for comments) / 中国中药杂志
Yan-Ming XIE; Jian-Nong WANG; Fu-Yuan HE; Jun-Jie JIANG; Xin XIONG.
China Journal of Chinese Materia Medica
; (24): 2937-2942, 2013.
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en Zh
| WPRIM | ID: wpr-238578
In population pharmacokinetic (PPK) research of Chinese medicines with narrow therapeutic windows of toxicity, or when the target population is not homogeneous, or when there are frequent adverse reactions to parenterally administered Chinese medicine, select those that have a definite therapeutic effect, and in which the compositions of the toxic substances compositions are known, for study, and use complete PPK sampling design to take samples at specific time points. Use gas chromatography, HPLC, and LC-MS methods for the detection of target components. Finally, use total quantity statistical moment analysis, to account for each component of the PPK parameters. Thus, PPK model can reflect the overall trend of Chinese medicine, to provide the basis for reasonable clinical dosage adjustments.
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