<p><b>OBJECTIVE</b>To determine the predictive value of interim and end-of-
treatment ¹⁸F-FDG
PET-CT after first-line
treatment in
patients with
Hodgkin lymphoma (HL).</p><p><b>
METHODS</b>The clinical data of 50 newly diagnosed HL
patients were retrospectively analyzed. Baseline, interim and end-of-
treatment PET-CT were performed, and then imaging results were analyzed for the
survival of
patients via
software SPSS 13.0.</p><p><b>RESULTS</b>Fifty
patients received first-line
treatment with ABVD (
doxorubicin +
bleomycin +
vincristine +
dacarbazine) or BEACOPP (
bleomycin +
etoposide +
doxorubicin +
cyclophosphamide +
vincristine +
procarbazine+
prednisone) regimen. Interim
PET-CT of 35
patients were performed after 2-4 cycles of
treatment, 46
patients received
PET-CT scans at the end of
treatment. After a median follow-up of 29.4 months (12.2-52.4 months), the 3-year
progression-free survival (PFS) rates were 100% and 70% for the interim
PET-CT negative (n=25) and positive (n=10)
patients, respectively (P=0.004). The 3-year PFS rates were 100% and 60% for the post-
treatment PET-CT negative (n=36) and positive (n=10)
patients, respectively (P<0.01).</p><p><b>CONCLUSION</b>Interim and end-of-
treatment PET-CT were correlated with 3-year PFS rates for HL
patients. They may
play an important
role in predicting the outcome of HL. The relationship with OS can not be determined because of the short follow-up
time.</p>