<p><b>OBJECTIVE</b>To explore the effects of uterine
adenomyosis on the clinical outcomes of
infertility patients treated with
in vitro fertilization /
intracytoplasmic sperm injection -
embryo transfer (IVF/
ICSI -ET).</p><p><b>
METHODS </b>A
retrospective study was conducted of 61 IVF/
ICSI -ET cycles as the study group, diagnosed with uterine
adenomyosis by transvaginal ultrasound, and 164 IVF/
ICSI -ET cycles of
patients with tubal
infertility as the
control group . The baseline characteristics,
ovary response and clinical outcomes were compared between the two groups.</p><p><b>RESULTS</b>The implantation rate, clinical
pregnancy rate and
live birth rate decreased significantly in the study group (P<0.05), and early
abortion rate increased significantly (P<0.05). For
patients with
adenomyosis ,
GnRH -antagonist cycles tended to decrease clinical
pregnancy rate and increase
abortion rate (25.0% vs 45.0%, P=0.184; 66.7% vs 27.8%, P=0.247), and significantly decrease
live birth rate (0% vs 30.8%, P=0.025), compared with GnRHa agonist cycles.</p><p><b>CONCLUSION</b>Uterine
adenomyosis decreases implantation rate, clinical
pregnancy rate and
birth rate , and increases
abortion rate significantly in
patients with IVF/
ICSI -ET.
GnRH -antagonist cycles have
adverse effects on the outcomes of
adenomyosis ;
GnRH agonist long protocol cycles may increase clinical
pregnancy rate and decrease
abortion rate .</p>