The GATA family in reproduction / 中华男科学杂志
Cai-xia JING; Jia-zhou YANG; Qing-yan AI; Nai-zhou MIAO; Yu-feng ZHAO; Yan-mei WANG.
National Journal of Andrology
; (12): 932-936, 2009.
Artículo
en Zh
| WPRIM | ID: wpr-241227
The GATA family proteins are a group of zinc finger transcription factors that are expressed in human and mammalian animals and play an important role in mammalian organ morphogenesis, cell proliferation and sex differentiation. GATA-4 and GATA-6 have been identified in the ovaries and testes of humans, mice, pigs and chickens. GATA-4 contributes to fetal male gonadal development by regulating the genes that mediate Müllerian duct regression and the onset of testosterone production. GATA-4 and GATA-6 are localized in and regulate the function of the ovarian and testicular somatic cells of fetal mice, especially granulosa cells, thecal cells, Sertoli cells and Leydig cells. GATA-4 is also present in the germ cells of fetal and prepubertal mice.
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