<p><b>OBJECTIVE</b>To explore the effect of
ginseng-sanqi extract (GSE) on the
vascular endothelium growth factor receptor-2 (
VEGFR-2),
Ras and
mitogen-activated protein kinase (MAPK) in
VEGFR-2-
Ras-MAPK
signal pathway of
angiogenesis in cultured
human umbilical
vascular endothelial cells (HUVECs).</p><p><b>
METHODS</b>The
protein expressions of
VEGFR-2,
Ras and MAPK in HUVEC and the effects of GSE (at different doses) and basic
fibrin growth factor (bFGF) on them were detected by Western-Blot test.</p><p><b>RESULTS</b>GSE can enhance the expression of
angiogenesis signaling
proteins (
VEGFR-2,
Ras, MAPK) to different extents, especially in the groups treated by bFGF or higher
dose GSE, the levels showed significant differences to those in the blank group (P<0.05).</p><p><b>CONCLUSION</b>GSE can promote the expressions of
VEGFR-2,
Ras and MAPK in the
angiogenesis signaling pathway, which may be the
foundation of
Chinese medicine for tonifying
qi and activating
blood circulation in promoting endothelial proliferation and
angiogenesis.</p>