Effects of vitamin D receptor gene polymorphisms on susceptibility to type 1 diabetes mellitus / 中国医学科学杂志(英文版)
Xin-Hua XIAO; Zhe-Long LIU; Heng WANG; Qi SUN; Wen-Hui LI; Guo-Hua YANG; Qiu-Ying LIU.
Chinese Medical Sciences Journal
; (4): 95-98, 2006.
Artículo
en Inglés
| WPRIM | ID: wpr-243610
<p><b>OBJECTIVE</b>To investigate the influence of vitamin D receptor (VDR) gene polymorphisms on susceptibility to type 1 diabetes mellitus (T1DM) in the Chinese Han population.</p><p><b>METHOD</b>One hundred and thirty-six Chinese Han people, including 54 T1DM patients and 82 unrelated healthy subjects as control were genotyped by polymerase chain reaction-restriction fragment length polymorphism for three restriction sites in the VDR gene, which were ApaI, TaqI, and BamI.</p><p><b>RESULTS</b>The frequency of B allele of BsmI site in VDR gene was significantly higher in T1DM patients than in healthy subjects (P = 0.033) while no difference was found between the two groups in the distribution of ApaI and TaqI polymorphisms.</p><p><b>CONCLUSION</b>The BsmI polymorphism of VDR gene may be associated with the susceptibility to T1DM in the Chinese Han population of Beijing.</p>
Biblioteca responsable:
WPRO
Texto completo
Documentos relacionados