<p><b>OBJECTIVE</b>To observe
serum adiponectin,
free fatty acid (FFA) profile and other
glucose and
lipid metabolic
parameters in essential hypertensive
patients with
metabolic syndrome (HPMS) or without
metabolic syndrome (HP).</p><p><b>
METHODS</b>The
serum adiponectin was measured with the
radioimmunoassay, FFA profile measured with the
gas chromatography and mass spectrometer in 72 HPMS, 56 HP and 43 normal control subjects.</p><p><b>RESULTS</b>
Serum adiponectin were significantly lower in HPMS group than those in the HP and
control group (P < 0.05 or P < 0.01).
Serum total
free fatty acid (TFA),
unsaturated fatty acid (UFA,
linoleic acid,
oleic acid,
arachidonic acid,
docosahexaenoic acid, eicosatrienoic
acid),
polyunsaturated fatty acid (PUFA) and n6PUFA were significantly higher in HPMS group than those in the HP and
control groups (P < 0.05 or P < 0.01).
Adiponectin was negatively correlated with
body mass index,
waist circumferences,
waist hip ratio,
triglycerides (r = -0.222, -0.235, -0.179, -0.194, P < 0.01 or P < 0.05, respectively) and positively correlated with
high-density lipoprotein cholesterol (r = 0.336, P < 0.01); TFA and PUFA were positively correlated with
body mass index,
waist circumferences,
fasting blood glucose,
mean arterial pressure (r = 0.241 and 0.280, 0.198 and 0.188, 0.226 and 0.298, 0.274 and 0.334, P < 0.01 or P < 0.05, respectively) in all subjects.</p><p><b>CONCLUSION</b>Our data suggest that changes in
serum adiponectin, FFA and n6PUFA might promote the development of
metabolic syndrome in essential hypertensive
patients.</p>