Genetic risk score: principle, methods and application / 中华流行病学杂志
Cheng WANG; Juncheng DAI; Yimin SUN; Lan XIE; Liangbin PAN; Zhibin HU; Hongbing SHEN.
Chinese Journal of Epidemiology
; (12): 1062-1064, 2015.
Artículo
en Zh
| WPRIM | ID: wpr-248710
Genetic risk score (GRS) is used for evaluating the effects of genetic susceptible factors in risk prediction models.Five methods are commonly used for GRSi.e.simple count genetic risk score (SC-GRS),odds ratio weighted genetic risk score (OR-GRS),direct logistic regression genetic risk score (DL-GRS),polygenic genetic risk score (PG-GRS) and explained variance weighted genetic risk score (EV-GRS).This paper summarizes the models,application conditions,advantages and limitations of the five methods.The complexity of prediction models increased along with the inclusion of more susceptible SNPs,some method have been developed to solve the problems,but the effects of new methods needs further evaluation.
Biblioteca responsable:
WPRO
Texto completo
Documentos relacionados