<p><b>OBJECTIVE</b>To compare the
efficacy of 3%
hypertonic saline solution with 20%
mannitol in
treatment of
intracranial hypertension in
patients with
aneurysmal subarachnoid hemorrhage .</p><p><b>
METHODS </b>An alternating
treatment protocol was used to compare the
efficacy of 160 mL 3%
hypertonic saline solution (HSS) with 150 mL 20%
mannitol for episodes of increased
intracranial pressure (ICP) in
patients with
aneurysmal subarachnoid hemorrhage . The dependent variables were the extent and duration of reduction of increased ICP after each event.</p><p><b>RESULTS</b>Both 3% HSS and 20%
mannitol rapidly decreased the ICP in
patients with
aneurysmal subarachnoid hemorrhage (P <0.01). No difference between two medications in the extent of duration of ICP and reduction of action (P >0.05).</p><p><b>CONCLUSION</b>3% HSS should be considered as the first-line osmotic
drug in
treatment of
intracranial hypertension in
patients with
aneurysmal subarachnoid hemorrhage .</p>