<p><b>OBJECTIVE</b>To explore pathogenesis of post-
transplantation diabetes mellitus (PTDM) in
renal transplantation recipients.</p><p><b>
METHODS</b>A total of 40
renal transplantation recipients were divided into three groups based on
oral glucose tolerance test results:
normal
glucose tolerance (NGT) group (n = 10), impaired
fasting glycaemia +
impaired glucose tolerance (IFG + IGT) group (n = 16), and PTDM group (n = 14).
Insulin resistance (IR) and beta
cell function were assessed by
homeostasis model.</p><p><b>RESULTS</b>The differences of the
immunosuppressive agents used in these groups were not statistically significant (P > 0.05). Compared with NGT group,
insulin area under curve and
homeostasis model assessment-
insulin resistance index were significantly higher in IGT + IFG group and PTDM group (P < 0.05). Compared with NGT group and IGT + IPG group,
insulin secretion index at 30 min and
homeostasis model assessment-
insulin secretion index were significantly lower in PTDM group (P < 0.05).</p><p><b>CONCLUSION</b>
Insulin resistance and beta-
cell dysfunction may
play a key
role in the pathogenesis of PTDM.</p>