<p><b>OBJECTIVE</b>To investigate the expression of
nerve growth factor (
NGF ) and
glial cell line-derived neurotrophic factor (
GDNF ) in
monkeys of
resuscitation after selective cerebral ultraprofound
hypothermia and
blood flow occlusion.</p><p><b>
METHODS </b>The
monkeys were immediately removed
brain after
death in operation of group A (identical
temperature perfusion group) and group B (ultraprofound
hypothermia perfusion group). Immunohistochemical
technique was used to determine frontal cellular expression of
NGF and
GDNF .
Statistics were analyzed by
ANOVA analyses with significance level at P < 0.05.</p><p><b>RESULTS</b>The expressions of
NGF and
GDNF in the group B were significantly higher than those in the group A (P < 0.05).</p><p><b>CONCLUSION</b>
NGF and
GDNF increased significantly in the
monkeys of
resuscitation after selective cerebral ultraprofound
hypothermia and
blood flow occlusion. It may be a protective mechanism for
neuron survival and neural
function recovery .</p>