Invasion and
metastasis are key factors contributing to the high mortality rate of
patients with
hepatocellular carcinoma (HCC) involving a complex mechanism. In the invasion and
metastasis of HCC,
miRNAs can serve as either
oncogenes or
tumor suppressor genes to regulate the differentiation and proliferation of
tumor cells being and
play important
roles in
tumorigenesis,
angiogenesis, invasion and
metastasis. This
review summarizes the recent progress in
research of the molecular mechanisms by which
miRNAs targeting
GSK-3β regulate HCC invasion and
metastasis and examines the
roles of
miRNAs in
hepatocellular carcinoma cell proliferation,
apoptosis, invasion,
metastasis, and
GSK-3β
regulation.