<p><b>OBJECTIVE</b>To screen the clinicopathological factors of synchronous hepatic
metastases from
colorectal cancer for
early diagnosis and
therapy.</p><p><b>
METHODS</b>Clinicopathological data of 367 cases with
colorectal cancer from Jan. 2003 to Dec. 2006 in our department were collected to set up the database. All the
patients were divided into two groups according to hepatic
metastases or not. Clinicopathological factors were analyzed, such as age,
sex,
blood type,
tumor family history,
hepatitis and
cirrhosis history, peritoneal or pelvic
metastases, bowel obstruction, CEA, CA19-9,
tumor localization and size, histological type, infiltration depth,
lymph node metastases etc.</p><p><b>RESULTS</b>Out of 367
colorectal cancer cases, there were 56 cases with synchronous hepatic
metastases from
colorectal cancer,
accounting for 15.3%. The age, bowel obstruction, peritoneal or pelvic
metastases, and
tumor invasion depth were associated with the hepatic
metastases. The primary
tumor located in the right
colon resulted in more right lobe hepatic
metastases than those in the left lobe. The
serum CEA level was associated with hepatic
metastases. When
serum CEA was more than 22.1 microg/L, the occurrence rate of hepatic
metastases increased.</p><p><b>CONCLUSION</b>Peritoneal or pelvic
metastases, bowel obstruction, age and
serum CEA level are associated with synchronous hepatic
metastases from
colorectal cancer.</p>