Detection of subtelomeric copy number variations in children with intellectual disability / 中国当代儿科杂志
Li-Na ZHU; Yan WANG; Wei PENG; Xiu-Wei MA; Xiao YANG; Xin LIU; Zhi-Chun FENG.
Chinese Journal of Contemporary Pediatrics
; (12): 1273-1276, 2015.
Artículo
en Zh
| WPRIM | ID: wpr-279927
<p><b>OBJECTIVE</b>To detect subtelomeric copy number variations in children with genetic intellectual disability (ID) using multiplex ligation-dependent probe amplification (MLPA), and to investigate the pathogenesis of genetic ID.</p><p><b>METHODS</b>A total of 68 children with ID who had normal results of G-banding karyotype analysis were included in the study. Their subtelomeric copy number variations were detected using MLPA P036.</p><p><b>RESULTS</b>Among the 68 children with ID, 7(10%) showed subtelomeric copy number variations, and all the variations were deletion mutations. Among them, 1 case carried 2 subtelomeric microdeletions, and 1 case carried 4 subtelomeric microdeletions.</p><p><b>CONCLUSIONS</b>Subtelomeric copy number variations are important causes of genetic ID. MLPA can be used as an economic and effective method for investigating the pathogenesis of genetic ID.</p>
Biblioteca responsable:
WPRO
Texto completo
Documentos relacionados