"Wise men could recognize similarities, but the fool only recognizes differences" in Su-wen, which expounded clinical thinkingmethods of Chinesemedicine (CM). "To recognize similarities and differences simultaneously" is of important clinical significance in understanding the laws of diseases. CM pays much attention to recognize similarities, while modern medicine emphasizes the differences observed. In order to develop integrative medicine (IM), similarities recognition and differences identification must be combined together to innovate new thinkingmethods of IM.