Microfluidic cell culture array chip for drug screening assays / 生物工程学报
Yunhuan ZHENG; Jianzhang WU; Jianbo SHAO; Qinghui JIN; Jianlong ZHAO.
Chinese Journal of Biotechnology
; (12): 779-785, 2009.
Artículo
en Zh
| WPRIM | ID: wpr-286642
We developed a novel microfluidic cell chip, which enabled drug delivery, fluid control and cell co-culture. The device consisted of an array of 6x6 cell culture chambers, a drug gradient generator and fluidic control valves. Micro-dam structures of the chambers were able to trap cells while loading and drug gradient network generated drug gradient of 6 different concentrations. Also we applied hydraulic valves to control the microfluid and simulate the microenvironment of cells. We had investigated the viability of co-culturing cells in the chip and the ability for drug screening. This microfluidic cell chip has the potential in cell-based research of high throughput drug screening.
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