<p><b>OBJECTIVE</b>To observe the
association between
angiotensin -converting
enzyme (ACE)
gene polymorphism and
endothelial nitric oxide synthase (eNOS)
gene polymorphism and
risk of
coronary artery disease (CAD) in Han
Chinese .</p><p><b>
METHODS </b>The polymorphism in the ACE and eNOS
gene were detected by using
polymerase chain reaction -
restriction fragment length polymorphism analysis ,
blood pressure (BP),
blood lipids ,
blood glucose (BS),
body mass index (BMI) and
left ventricle eject fraction (LVEF) were determined 236
patients with CAD and 190 healthy individuals.</p><p><b>RESULTS</b>The frequencies of DD
genotype of ACE were higher and the II
genotype were lower in CAD
patients than in controls (P < 0.05). CAD
patients with DD
genotypes were related with higher
serum TG, lower HDL-C, higher BS levels, higher BWI and lower LVEF compared to CAD
patients with II and
ID genotypes of ACE (all P < 0.05), while SBP, DBP, TC and LDL-C levels were
similar among CAD
patients and controls with different
genotypes of ACE (P > 0.05). The
genotype distributions of ACE and eNOS were also
similar among CAD
patients with or without
diabetes mellitus /ACS, with single or multiple vessel
diseases (P > 0.05). The frequency of GT
genotype of eNOS was higher in CAD
patients than in controls (P < 0.01) while the frequency of GG
genotype in CAD
patients and controls was
similar (P > 0.05) and eNOS
genotypes were not related to TC, TG, HDL-C, LDL-C, BS, BMI, SBP, DBP and LVEF levels among CAD
patients and controls (P > 0.05). The
risk of suffering from CAD in
population with ACE DD
genotype is 1.74 times higher than that with II
genotype (P < 0.01) and 1.73 times higher in
population with eNOS GT
genotype than that with GT
genotype (P < 0.05). The
risk of suffering from CAD is 37.9% with II and GG
genotypes and 77.8% with DD and GT
genotypes .</p><p><b>CONCLUSION</b>The ACE and eNOS
genotype polymorphisms were associated with
risk of CAD and
persons with DD and GT
genotypes take higher
risk of suffering from CAD.</p>