Association of genetic polymorphism in plasminogen activator inhibitor-1 gene with endometrial hypoplasia in infertile women / 中华医学遗传学杂志
Jing-hua SUN; Li--xue GUAN; Dong-ju LIN; Pei-feng DAI; Li PAN; Qian MU.
Chinese Journal of Medical Genetics
; (6): 462-464, 2008.
Artículo
en Zh
| WPRIM | ID: wpr-308038
<p><b>OBJECTIVE</b>To investigate the relationship between the plasminogen activator inhibitor (PAI-1) polymorphisms and endometrial hypoplasia in infertile women.</p><p><b>METHODS</b>The study was conducted in 105 primary infertile patients with endometrial hypoplasia diagnosed by pathology and the thickness of endometrium by B-mode ultrasound and 85 controls who were not pregnant and had normal fertility. The -675 4G/5G polymorphism in the PAI-1 gene was detected by polymerase chain reaction-restriction fragment length polymerphim analysis.</p><p><b>RESULTS</b>The frequencies of 4G/4G genotype and 4G allele of the PAI-1 gene were higher in the patient group (48.6% and 66.2%) than in the normal controls (22.4% and 47.1%) (P < 0.01). ThePAI-1 4G/4G genotype was significantly associated with endometrial hypoplasia in the infertile patients (OR=4.9, 95% CI 2.10-10.12).</p><p><b>CONCLUSION</b>The present findings suggest that the 4G/5G polymorphism of the PAI-1 gene was associated with endometrial hypoplasia in infertile patients.</p>
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