<p><b>OBJECTIVE</b>To explore the
prevalence of isolated diastolic
hypertension and associated
cardiovascular risk and
blood pressure changes during follow up.</p><p><b>
METHODS</b>This
cohort study screened 101 510 participants
who were
employees of the Kailuan Group, a
state-run
coal mining company in 2006 and 2007. Among them, 6 778 subjects were diagnosed with isolated diastolic
hypertension (IDH). IDH subjects without
history of
cardiovascular disease and not treated with
antihypertensive drugs were included in this
analysis. Participants without
health examination between 2008 to 2009 or 2010 to 2011 were excluded. A total of 4 600 participants were included in the final
analysis. At the end of the third
health examination, the conversion rate of different
blood pressure turnover was calculated after standardizing age and
gender according to
demographic data of
China in 2006. Multivariate
logistic regression analysis was applied to analyze the
risk factors of
blood pressure turnover in IDH
population.</p><p><b>RESULTS</b>(1) Participants were followed up for (4.03 ± 0.26) years and the rates of turnover from IDH to normotension,
isolated systolic hypertension (ISH) and systolic diastolic
hypertension (SDH) were 51.4%, 3.5%, 18.3%, respectively (45.6%, 3.6%, 22.0% in
male, 57.4%, 3.3%, 14.7% in
female). (2) Multivariate
logistic regression analysis showed that low baseline age, low
diastolic pressure, low
body mass index, low
uric acid,
physical exercise and low
alcohol intake were associated with turnover from IDH to normotension; the
risk factors of turnover from IDH to ISH were older age at baseline, higher
systolic pressure and higher
sensitivity C-reactive protein; the
risk factors of turnover from IDH to SDH were older baseline age, high
systolic pressure and excessive
salt intake.</p><p><b>CONCLUSIONS</b>Untreated subjects with IDH can transform from IDH to normotension,ISH, SDH, and the rate of turnover from IDH to normotension is higher than others during follow up.
Aging, higher
systolic pressure, higher
sensitivity C-reactive protein and excessive
salt intake are
risk factors for IDH subjects to suffer from ISH and SDH.</p>