Detection of BK virus infection in renal transplant recipients and clinical application / 中华实验和临床病毒学杂志
Zhong-biao WU; Guo-bing LIN; Ai-ping ZENG; Zhen-qian CHEN; Jun CHEN; Min-qiao ZHENG; Guo-wei TU; Rui-ming RONG.
Chinese Journal of Experimental and Clinical Virology
; (6): 367-369, 2010.
Artículo
en Zh
| WPRIM | ID: wpr-316896
<p><b>OBJECTIVE</b>To study the detection methods of BK virus infection in kidney transplant recipients, and to explore the clinical application.</p><p><b>METHODS</b>132 cases of renal transplant recipients were undertaken BK virus detection including presence of decoy cells in urinary sediment, urine and serum BKV-DNA to demonstrate the BK virus replication.</p><p><b>RESULT</b>Among 132 cases of renal transplant recipients, urinary decoy cell was found in 37 (28.0%) patients and the median time was 12 months after surgery. 32 (24.2%) patients were diagnosed as BK viruria at a median of 11 months after surgery, and 16 (12.1%) recipients were diagnosed as BK viremia at a median of 15 months after surgery, 5 patients with BK viruria were diagnosed as BK virus associated nephropathy according to allograft biopsy.</p><p><b>CONCLUSION</b>To make early diagnosis of BK virus infection, detection of urine decoy cells and BKV-DNA in urine and plasma sample is important,which provides an important basis for the prevention of BK virus associated nephropathy.</p>
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