Pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A in Carthami Flos / 中国中药杂志
Li XIA; Xiang-Mei CHEN; Li-Rong PENG; Shi-Xiang WANG; Xiao-Wen WANG; Yan ZUO; Peng ZHANG; Qin-She LIU; Xiao-Hui ZHENG.
China Journal of Chinese Materia Medica
; (24): 269-272, 2013.
Artículo
en Zh
| WPRIM | ID: wpr-318680
<p><b>OBJECTIVE</b>To investigate the pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A (HSYA) in Carthami Flos.</p><p><b>METHOD</b>Concentration of HSYA in rat plasma was detected by RP-HPLC after rats were orally administered with extracts of Carthami Flos or Carthami Flos combined with Sappan Lignum. Pharmacokinetic parameters were calculated by DAS 2.0 pharmacokinetic software.</p><p><b>RESULT</b>In vivo pharmacokinetic models of HSYA were two-compartment open models in both of the Carthami Flos group and the Carthami Flos combined with Sappan Lignum group. After compatibility, HSYA showed a significant lower in apparent volumes of distribution of t(1/2Ka), t(1/2alpha) and V1/F, with slight advance in T(max).</p><p><b>CONCLUSION</b>Sappan Lignum can accelerate absorption, distribution and metabolic process of HSYA in vivo and reduce its accumulation in vivo.</p>
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