<p><b>OBJECTIVE</b>To summarize the clinicopathological features and
prognosis of malignant
ovarian neoplasms complicating
pregnancy and explore the rational
treatment.</p><p><b>
METHODS</b>The clinical data of 38
patients with malignant
ovarian neoplasms complicating
pregnancy were retrospectively analyzed,and the intra-surgical pathological sections were reviewed. International
Federation of
Gynecology and
Obstetrics (FIGO) staging system (1988) was applied.</p><p><b>RESULTS</b>Of these 38
patients,the
malignancies included
epithelial ovarian cancer (n=9, 23.7%), epithelial borderline ovarian
tumor (n=13, 34.2%),ovarian malignant
germ cell tumors (n=11, 28.9%),
sex cord stromal
tumors (n=3, 7.9%), and metastatic
tumor from
gastrointestinal tracts (n=2, 5.3%). Twenty-seven
patients (71.1%) were at stage I. The
pregnancy outcomes included termination in the
first trimester (n=8), full-term vaginal delivery (n=6), full-term
Cesarean section (n=15), and therapeutical
Cesarean section for
premature birth (n=9). One
newborn died,and the remaining 29 survived in a healthy status. All
patients underwent surgical
treatment,among whom two
patients received surgeries during
pregnancy.
Patients were followed up for (40.5±38.5) months,during which one
patient was
lost to follow-up, 7 died, 1 survived with
tumor, and 29 (76.3%) survived free of
tumors.</p><p><b>CONCLUSIONS</b>The management of ovarian
malignancies complicating
pregnancy should be individualized. Both surgical
treatment and
chemotherapy are relatively safe in the second and
third trimesters. Satisfactory
prognosis can be expected after appropriate
treatment.</p>