Reversible
protein phosphorylation regulates multiple biochemical events.
Mycobacterium tuberculosis phosphatases play important
roles in regulating the pathogen
physiology and interference of host signaling. They are also involved in the evasion of host
immune response and blockage of the
phagosome-
lysosome fusion. Selective inhibition of
phosphatase represents an ideal new avenue of
anti-tuberculosis drug design. In this
paper, we update the progresses about the
regulation network of
Mycobacterium tuberculosis phosphatases including MptpA, MptpB, MstP, SapM and their inhibitors. These serve as the basis for further antituberculosis
drug target.