<p><b>OBJECTIVE</b>To analyze LC-MSfingerprints of Aristolochia manshuriensis for quality assessment with two different chemical pattern recognition models.</p><p><b>METHOD</b>LC-MSfingerprints of A. manshuriensis were established from 24 batches of samples from different habitats. SIMCA and Clusteringanalysis were used to compare the parameters of the 29 common peaks.</p><p><b>RESULT</b>Two methods had good consistency, while they reflected the inherent sample information from different perspectives, respectively.</p><p><b>CONCLUSION</b>Modern equipmentanalysistechnology and multivariable chemical pattern recognition would be an efficient way for quality control and variety identification of A. manshuriensis.</p>